Idiopathic pulmonary fibrosis (IPF) may be triggered by epithelial injury that results in
aberrant production of growth factors, cytokines, and proteinases, leading to proliferation of …

This manuscript will review our current understanding of neutrophilic polymorphonuclear
leukocyte (neutrophil) interactions with the endothelium during immune and inflammatory …

… Drs Aschner, Zemans, and Yamashita have reported that no potential conflicts of interest
exist with any companies/organizations whose products or services may be discussed in this …

Background Patients with eosinophilic asthma often report poor symptomatic control and
quality of life. Anti-IL-5 therapy, including anti-IL-5Rα (benralizumab), rapidly depletes …

Antibiotic-resistant bacterial infections represent an emerging health concern in clinical
settings, and a lack of novel developments in the pharmaceutical pipeline is creating a “perfect …

Leukocyte elastase induces apoptosis of lung epithelial cells via alterations in mitochondrial
permeability, but the signaling pathways regulating this response remain uncertain. Here …

Acute respiratory distress syndrome (ARDS) is a disease with a variety of causes and is
defined by severe hypoxemia. Whereas ARDS carries a mortality of approximately 30 %, …

Background We previously showed in patients with poorly controlled eosinophilic asthma
that a single dose of benralizumab resulted in significantly improved Asthma Control …

Rationale and Objectives The minimal clinically important difference (MCID) and upper limit
of normal (ULN) for MRI ventilation defect percent (VDP) were previously reported for …

The development of antibiotic resistance by Pseudomonas aeruginosa is a major concern
in the treatment of bacterial pneumonia. In the search for novel anti-infective therapies, the …