Introduction Our aim was to investigate the impact of early versus late initiation of renal
replacement therapy (RRT) on clinical outcomes in critically ill patients with acute kidney injury (…

High circulating ammonia concentrations are common in patients with acute liver failure (ALF)
and are associated with hepatic encephalopathy (HE) and intracranial hypertension (ICH). …

BACKGROUND & AIMS: Fractionated plasma separation and adsorption (FPSA) is an
extracorporeal procedure that supports liver function by removing endogenous toxins that cause …

Methods Prior to the conference, the organizing committee identified topics relevant to the
management of patients with ACLF. A diverse international panel representing multiple …

Background: Critically ill patients commonly experience skeletal muscle wasting that may
predict clinical outcome. Ultrasound is a noninvasive method that can measure muscle …

Background & Aims Patients with cirrhosis who are receiving palliative care and are not
eligible for liver transplantation (LT) are often hospitalized multiple times, with lack of …

… Author links open overlay panel Yang Du BSc a , Constantine J. Karvellas MD, SM,
FRCPC b c , Vickie Baracos PhD d , David C. Williams MD, MSc, FRCSC, FACS a , Rachel G. …

Hyperammonemia has been associated with intracranial hypertension and mortality in
patients with acute liver failure (ALF). We evaluated the effect of renal replacement therapy (RRT) …

Background Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN),
and existing clinical trial data are inconclusive. Our recent observational data show that …

Objectives: To develop evidence-based recommendations for clinicians caring for adults with
acute or acute on chronic liver failure in the ICU. Design: The guideline panel comprised …