User profiles for Christopher Sun

Christopher LF Sun

Postdoctoral Fellow, Massachusetts Institute of Technology
Verified email at mit.edu
Cited by 909

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

…, B Edris, SM Schmid, CK Sun… - Proceedings of the …, 2012 - National Acad Sciences
CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …

[HTML][HTML] TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury

…, X Zhong, CLF Sun, LRG Britto, ZP Feng, HS Sun - Molecular brain, 2015 - Springer
Background Our previous study found that suppression of TRPM7 reduced neuronal death
in adult rat ischemic brain injury. It was reported that carvacrol blocked TRPM7 and …

Overcoming spatial and temporal barriers to public access defibrillators via optimization

CLF Sun, D Demirtas, SC Brooks, LJ Morrison… - Journal of the American …, 2016 - jacc.org
Background : Immediate access to an automated external defibrillator (AED) increases the
chance of survival for out-of-hospital cardiac arrest (OHCA). Current deployment usually …

Neuronal KATP channels mediate hypoxic preconditioning and reduce subsequent neonatal hypoxic–ischemic brain injury

HS Sun, B Xu, W Chen, A Xiao, E Turlova… - Experimental …, 2015 - Elsevier
Neonatal hypoxic–ischemic brain injury and its related illness hypoxic–ischemic encephalopathy
(HIE) are major causes of nervous system damage and neurological morbidity in …

[PDF][PDF] Significance of circulating endothelial progenitor cells in hepatocellular carcinoma

JWY Ho, RWC Pang, C Lau, CK Sun, WC Yu… - …, 2006 - Wiley Online Library
This study evaluated the significance of circulating bone marrow‐derived endothelial
progenitor cells (EPCs) in patients with hepatocellular carcinoma (HCC), a solid tumor with rich …

Cerebrovascular Safety of Sulfonylureas: The Role of KATP Channels in Neuroprotection and the Risk of Stroke in Patients With Type 2 Diabetes

…, B Xu, W Chen, E Turlova, N Dong, CLF Sun… - Diabetes, 2016 - Am Diabetes Assoc
Sulfonylureas are ATP-sensitive potassium (K ATP ) channel blockers commonly used in
the treatment of type 2 diabetes mellitus (T2DM). Activation of K ATP channels plays a …

[PDF][PDF] Ischemia‐reperfusion of small liver remnant promotes liver tumor growth and metastases—Activation of cell invasion and migration pathways

…, KT Ng, CM Lo, JW Ho, BS Sun, CK Sun… - Liver …, 2007 - Wiley Online Library
Elucidating the mechanism of liver tumor growth and metastasis after hepatic ischemia‐reperfusion
(I/R) injury of a small liver remnant will lay the foundation for the development of …

Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN …

…, BS Sun, ZXH Lim, JS Cheung, EX Wu, CKW Sun… - Clinical Cancer …, 2010 - AACR
Purpose: We aimed to investigate the effects of adiponectin on liver cancer growth and
metastasis and explore the underlying mechanisms. Experimental Design: An orthotopic liver …

Suppression of glypican 3 inhibits growth of hepatocellular carcinoma cells through up-regulation of TGF-β2

CK Sun, MS Chua, J He, KS Samuel - Neoplasia, 2011 - Elsevier
Glypican 3 (GPC3) is a valuable diagnostic marker and a potential therapeutic target in
hepatocellular carcinoma (HCC). To evaluate the efficacy of targeting GPC3 at the translational …

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

CK Sun, K Man, KT Ng, JW Ho, ZX Lim… - …, 2008 - academic.oup.com
The aim of the current study is to elucidate the mechanism of proline-rich tyrosine kinase 2 (Pyk2)-mediated
cell proliferation and invasiveness in hepatocellular carcinoma (HCC) cells. …