User profiles for Christopher Sun
Christopher LF SunPostdoctoral Fellow, Massachusetts Institute of Technology Verified email at mit.edu Cited by 909 |
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …
[HTML][HTML] TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury
…, X Zhong, CLF Sun, LRG Britto, ZP Feng, HS Sun - Molecular brain, 2015 - Springer
Background Our previous study found that suppression of TRPM7 reduced neuronal death
in adult rat ischemic brain injury. It was reported that carvacrol blocked TRPM7 and …
in adult rat ischemic brain injury. It was reported that carvacrol blocked TRPM7 and …
Overcoming spatial and temporal barriers to public access defibrillators via optimization
Background : Immediate access to an automated external defibrillator (AED) increases the
chance of survival for out-of-hospital cardiac arrest (OHCA). Current deployment usually …
chance of survival for out-of-hospital cardiac arrest (OHCA). Current deployment usually …
Neuronal KATP channels mediate hypoxic preconditioning and reduce subsequent neonatal hypoxic–ischemic brain injury
HS Sun, B Xu, W Chen, A Xiao, E Turlova… - Experimental …, 2015 - Elsevier
Neonatal hypoxic–ischemic brain injury and its related illness hypoxic–ischemic encephalopathy
(HIE) are major causes of nervous system damage and neurological morbidity in …
(HIE) are major causes of nervous system damage and neurological morbidity in …
[PDF][PDF] Significance of circulating endothelial progenitor cells in hepatocellular carcinoma
This study evaluated the significance of circulating bone marrow‐derived endothelial
progenitor cells (EPCs) in patients with hepatocellular carcinoma (HCC), a solid tumor with rich …
progenitor cells (EPCs) in patients with hepatocellular carcinoma (HCC), a solid tumor with rich …
Cerebrovascular Safety of Sulfonylureas: The Role of KATP Channels in Neuroprotection and the Risk of Stroke in Patients With Type 2 Diabetes
…, B Xu, W Chen, E Turlova, N Dong, CLF Sun… - Diabetes, 2016 - Am Diabetes Assoc
Sulfonylureas are ATP-sensitive potassium (K ATP ) channel blockers commonly used in
the treatment of type 2 diabetes mellitus (T2DM). Activation of K ATP channels plays a …
the treatment of type 2 diabetes mellitus (T2DM). Activation of K ATP channels plays a …
[PDF][PDF] Ischemia‐reperfusion of small liver remnant promotes liver tumor growth and metastases—Activation of cell invasion and migration pathways
Elucidating the mechanism of liver tumor growth and metastasis after hepatic ischemia‐reperfusion
(I/R) injury of a small liver remnant will lay the foundation for the development of …
(I/R) injury of a small liver remnant will lay the foundation for the development of …
Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN …
Purpose: We aimed to investigate the effects of adiponectin on liver cancer growth and
metastasis and explore the underlying mechanisms. Experimental Design: An orthotopic liver …
metastasis and explore the underlying mechanisms. Experimental Design: An orthotopic liver …
Suppression of glypican 3 inhibits growth of hepatocellular carcinoma cells through up-regulation of TGF-β2
CK Sun, MS Chua, J He, KS Samuel - Neoplasia, 2011 - Elsevier
Glypican 3 (GPC3) is a valuable diagnostic marker and a potential therapeutic target in
hepatocellular carcinoma (HCC). To evaluate the efficacy of targeting GPC3 at the translational …
hepatocellular carcinoma (HCC). To evaluate the efficacy of targeting GPC3 at the translational …
Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation
The aim of the current study is to elucidate the mechanism of proline-rich tyrosine kinase 2 (Pyk2)-mediated
cell proliferation and invasiveness in hepatocellular carcinoma (HCC) cells. …
cell proliferation and invasiveness in hepatocellular carcinoma (HCC) cells. …