Background: In addition to nonmodifiable genetic risk factors, potentially modifiable factors
such as hypertension, hyperlipidemia and environmental exposures have been identified as …

… Kenneth Rockwood, Chris MacKnight, David Hogan and Howard Bergman examined
patients. Ian McDowell, Chris MacKnight and David Hogan commented on and revised interim …

Between 1977 and 1984, 48 girls but only 26 boys were born to parents exposed to 2, 3, 7,
8 tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) in Seveso, Italy. 1 The 1976 industrial …

Background. Frailty and fitness are important attributes of older persons, but population
samples of their prevalence, attributes, and outcomes are limited. Methods. The authors report …

Background Recent reports suggest a possibly protective effect for statins in patients with
Alzheimer disease. This association could be due to indication bias, ie, people who elect to …

Background: Although cholinesterase inhibitors have produced statistically significant
treatment effects, their clinical meaningfulness in Alzheimer's disease is disputed. An important …

Background: Conflicting results have been reported about the status of diabetes mellitus as
a risk for Alzheimer’s disease. We investigated the relationship between diabetes and …

The use of the term ‘frailty’ has shown tremendous growth in the last 15 years, but this has
not been accompanied by a widely accepted definition, let alone agreed-upon measures. In …

In a representative Canadian population survey (n=66 589) the proportion of accumulated
deficits in a frailty index showed a linear relationship with mortality in a log–log plot, such that …

… Author links open overlay panel Christopher Patterson a , John Feightner b , Angeles
Garcia c , Chris MacKnight d … During preparation of this article, Christopher Patterson …