It has been known for many years that neutrophils and platelets participate in the pathogenesis
of severe sepsis, but the inter-relationship between these players is completely unknown. …

Background Some observational studies suggest that the use of pulmonary-artery catheters
to guide therapy is associated with increased mortality. Methods We performed a …

Introduction Severe acute renal failure (sARF) is associated with considerable morbidity,
mortality and use of healthcare resources; however, its precise epidemiology and long-term …

We conducted a prospective, observational cohort study designed to compare intestinal
permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a subset …

Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections and …

Objective: To describe the incidence of non-neurologic organ dysfunction and its association
with outcome in patients with severe traumatic brain injury admitted to intensive care. …

Objective Although bloodstream infection commonly results in critical illness, population-based
studies of the epidemiology of severe bloodstream infection are lacking. We sought to …

Background Intensive care unit (ICU) beds, a scarce resource, may require prioritization of
admissions when demand exceeds supply. We evaluated the effect of ICU bed availability on …

Purpose: A urinary tract infection (UTI) is the most common hospital-acquired infection.
However, the epidemiology of intensive care unit (ICU)-acquired UTIs is not well defined. The …

Background. A common tenet in emergency medical services (EMS) is that faster response
equates to better patient outcome, translated by some EMS operations into a goal of a …