Resistance to clopidogrel: a review of the evidence

TA Nguyen, JG Diodati, C Pharand - Journal of the American College of …, 2005 - jacc.org
Current available data show that about 4% to 30% of patients treated with conventional doses
of clopidogrel do not display adequate antiplatelet response. Clopidogrel resistance is a …

A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease

M Lordkipanidzé, C Pharand… - European heart …, 2007 - academic.oup.com
Aims We sought to compare the results obtained from six major platelet function tests in the
assessment of the prevalence of aspirin resistance in patients with stable coronary artery …

Comparison of four tests to assess inhibition of platelet function by clopidogrel in stable coronary artery disease patients

M Lordkipanidze, C Pharand, TA Nguyen… - European heart …, 2008 - academic.oup.com
Aims We investigated the comparability of platelet function tests in quantifying platelet
inhibition achieved by clopidogrel. Methods and results This pre-specified substudy of a …

Brain natriuretic peptide in the management of heart failure: the versatile neurohormone

S de Denus, C Pharand, DR Williamson - Chest, 2004 - Elsevier
Brain natriuretic peptide (BNP), also called B-type natriuretic peptide, is a member of a
family of structurally related hormones, the natriuretic peptides. Current data suggest that …

Possibility of a rebound phenomenon following antiplatelet therapy withdrawal: a look at the clinical and pharmacological evidence

M Lordkipanidzé, JG Diodati, C Pharand - Pharmacology & therapeutics, 2009 - Elsevier
The importance of regular administration of antiplatelet drugs in patients suffering from
coronary artery disease stands on firm grounds, as large meta-analyses have shown these …

Wavelet time entropy, T wave morphology and myocardial ischemia

D Lemire, C Pharand, JC Rajaonah… - IEEE Transactions …, 2000 - ieeexplore.ieee.org
Using wavelets, the authors computed the entropy of the signal at various frequency levels (wavelet
time entropy) and, thus, find an optimal measure to differentiate normal states from …

Response to aspirin in healthy individuals

N Blais, C Pharand, M Lordkipanidzé… - Thrombosis and …, 2009 - thieme-connect.com
Variable biological effect of aspirin is suggested to be related to pharmacological resistance.
The incidence of this so-called “resistant” state varies with the study population and the …

Use of OTC and herbal products in patients with cardiovascular disease

C Pharand, ML Ackman… - Annals of …, 2003 - journals.sagepub.com
BACKGROUND: The use of nonprescription and herbal products by the public is rising,
resulting in an increased potential for adverse reactions or drug interactions in cardiac patients. …

Glycoprotein IIb/IIIa receptor blockade improves outcomes in diabetic patients presenting with unstable angina/non–ST-elevation myocardial infarction: results from …

P Théroux, J Alexander Jr, C Pharand, E Barr… - Circulation, 2000 - Am Heart Assoc
Background—Diabetic patients who present with unstable angina or non–ST-elevation
myocardial infarction suffer a substantially greater incidence of subsequent infarction or death …

Genetic determinants of response to aspirin: appraisal of 4 candidate genes

…, DA Palisaitis, E Schampaert, J Turgeon, C Pharand - Thrombosis research, 2011 - Elsevier
INTRODUCTION: Intersubject variability in platelet response to aspirin could be related to
genetic factors that regulate platelet enzymes or receptors. This study evaluates the impact of …