Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing …

Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities
with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki …

A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome” (CSS). In this review we compare …

Allergists and clinical immunologists around the world are increasingly faced with the task
of addressing drug allergy and hypersensitivity due to the increase in drug reactions. …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays
a central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency that
exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending beyond …

Background Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome
(MAS) were historically thought to be distinct entities, often managed in isolation. In fact, …

Individuals with X-linked lymphoproliferative disease lack invariant natural killer T (iNKT)
cells and are exquisitely susceptible to Epstein-Barr virus (EBV) infection. To determine …

Disclosures: C. Flores reported grants from Instituto de Salud Carlos III, Spanish Ministry of
Science and Innovation, and Cabildo Insular de Tenerife outside the submitted work. J. …