… Another example of a potentially useful molecular determinant is the C → T polymorphism
at codon 118 of the ERCC1 gene, which seems to play a role in response to oxaliplatin. The …

Background Early cancer detection could identify tumors at a time when outcomes are
superior and treatment is less morbid. This prospective case-control sub-study (from …

Sonic hedgehog (Shh), a soluble ligand overexpressed by neoplastic cells in pancreatic
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma. To …

Background Patients with advanced gastric or gastro-oesophageal junction cancer that
progresses on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel …

… c Sylamer analysis plot shows a statistically significant enriched miRNA signature for miR-34a
for putative target genes, suggesting specific activity of the miR-34a mimic against its …

Background Inhibition of MEK stops cell proliferation and induces apoptosis; therefore, this
enzyme is a key anticancer target. Trametinib is a selective, orally administered MEK1/MEK2 …

… C for 2 min, allowed to come to room temperature over 30 min, and then aliquoted and stored
at −20C… sites respectively inserted upstream of a minimal c-fos promoter. The cells were …

The prevalence of gastrointestinal parasites in dogs was studied in the province of Córdoba
(southern Spain), with special attention to those parasites that can be transmitted to man. …

… c–e, Pathological grade of tumour stage (c), histological quantification of cancer and stromal
PSC cell abundance (d), and levels of PCC-produced GM-CSF and PSC-produced CCL11 …

… Herein, we report the modulatory effects of the triterpenoid C-28 methyl ester of 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic
acid (CDDO-Me; bardoxolone methyl) on MDSCs. In different …