[HTML][HTML] ATM phosphorylates histone H2AX in response to DNA double-strand breaks
…, BP Chen, M Murphy, A Kurimasa, DJ Chen - Journal of Biological …, 2001 - ASBMB
A very early step in the response of mammalian cells to DNA double-strand breaks is the
phosphorylation of histone H2AX at serine 139 at the sites of DNA damage. Although the …
phosphorylation of histone H2AX at serine 139 at the sites of DNA damage. Although the …
[HTML][HTML] Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a new human disease with few effective treatments 1 . …
coronavirus 2 (SARS-CoV-2), is a new human disease with few effective treatments 1 . …
PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies
BJ Chen, B Chapuy, J Ouyang, HH Sun… - Clinical cancer …, 2013 - AACR
Purpose: Programmed cell death ligand 1 (PD-L1) is an immunomodulatory molecule
expressed by antigen-presenting cells and select tumors that engages receptors on T cells to …
expressed by antigen-presenting cells and select tumors that engages receptors on T cells to …
Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset
A Galy, M Travis, D Cen, B Chen - Immunity, 1995 - cell.com
The early stages of lymphoid cell formation were studied by testing the differentiative potential
of phenotypically defined subsets of CD34+ bone marrow cells. A subpopulation of CD34…
of phenotypically defined subsets of CD34+ bone marrow cells. A subpopulation of CD34…
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
Nonhomologous end-joining (NHEJ) is the predominant pathway that repairs DNA double-strand
breaks (DSBs) in mammalian cells. The DNA-dependent protein kinase (DNA-PK), …
breaks (DSBs) in mammalian cells. The DNA-dependent protein kinase (DNA-PK), …
[HTML][HTML] Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
U Herbig, WA Jobling, BPC Chen, DJ Chen, JM Sedivy - Molecular cell, 2004 - cell.com
Cellular senescence can be triggered by telomere shortening as well as a variety of stresses
and signaling imbalances. We used multiparameter single-cell detection methods to …
and signaling imbalances. We used multiparameter single-cell detection methods to …
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
RI Connor, BK Chen, S Choe, NR Landau - Virology, 1995 - Elsevier
HIV-1 vpr encodes a 96-amino acid, nuclear protein whose function is not well understood.
Unlike the other lentivirus regulatory proteins, Vpr is present in virions at relatively high copy …
Unlike the other lentivirus regulatory proteins, Vpr is present in virions at relatively high copy …
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
Cytotoxic T lymphocytes (CTLs) lyse virally infected cells that display viral peptide epitopes
in association with major histocompatibility complex (MHC) class I molecules on the cell …
in association with major histocompatibility complex (MHC) class I molecules on the cell …
[PDF][PDF] The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
To avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from
the surface of infected cells. However, class I downregulation potentially exposes the virus…
the surface of infected cells. However, class I downregulation potentially exposes the virus…
Development of a definition of postacute sequelae of SARS-CoV-2 infection
…, AA Chang, P Chebrolu, Y Chen, LQ Chen, BK Chen… - Jama, 2023 - jamanetwork.com
Importance SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms
or other health effects occurring after acute infection, termedpostacute sequelae of SARS-…
or other health effects occurring after acute infection, termedpostacute sequelae of SARS-…