A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…

Background Hospitals have difficulty justifying the expense of maintaining trauma centers
without strong evidence of their effectiveness. To address this gap, we examined differences in …

Evidence-based guidelines for managing patients with intra-abdominal infection were prepared
by an Expert Panel of the Surgical Infection Society and the Infectious Diseases Society …

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

Background: Transfusion-related acute lung injury (TRALI) is now the leading cause of
transfusion-associated mortality, even though it is probably still underdiagnosed and …

Background The successful treatment of intraabdominal infection requires a combination of
anatomical source control and antibiotics. The appropriate duration of antimicrobial therapy …

… Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in
human monocytes. J Immunol 1993; 151: 6986–6993. … In vivo antioxidant treatment …

… Avery B. Nathens has received honoraria and travel expenses for consulting services from
Merck, Pfizer, and Wyeth. Joseph T. DiPiro has received honoraria and travel expenses for …

ContextThe premise underlying regionalization of trauma care is that larger volumes of trauma
patients cared for in fewer institutions will lead to improved outcomes. However, whether …

Objective: Acute pancreatitis represents a spectrum of disease ranging from a mild, self-limited
course requiring only brief hospitalization to a rapidly progressive, fulminant illness …