Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic …

INTRODUCTION Immunological memory is the basis for durable protective immunity after
infections or vaccinations. Duration of immunological memory after severe acute respiratory …

Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all three …

Many unknowns exist about human immune responses to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4 + T cells have been …

The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the
importance of addressing whether the total CD4 + and CD8 + T cell recognition is also affected. …

Multiple COVID-19 vaccines, representing diverse vaccine platforms, successfully protect
against symptomatic COVID-19 cases and deaths. Head-to-head comparisons of T cell, B cell, …

T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of
immunodominance of different SARS-CoV-2 antigens and precisely measure virus-specific CD4 + …

Genetic studies have shown the association of Parkinson’s disease with alleles of the major
histocompatibility complex 1 , 2 , 3 . Here we show that a defined set of peptides that are …

A diagnosis of motor Parkinson’s disease (PD) is preceded by a prolonged premotor phase
with accumulating neuronal damage. Here we examined the temporal relation between α-…

The ARF tumor suppressor is a nucleolar protein that activates p53-dependent checkpoints
by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and …