Future directions in Alzheimer's disease from risk factors to prevention

B Imtiaz, AM Tolppanen, M Kivipelto… - Biochemical …, 2014 - Elsevier
The increase in life expectancy has resulted in a high occurrence of dementia and Alzheimer's
disease (AD). Research on AD has undergone a paradigm shift from viewing it as a …

Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies

AM Tolppanen, A Solomon… - Journal of …, 2012 - content.iospress.com
The shared risk factor profile between cardiovascular diseases and Alzheimer's disease (AD),
observations on vascular pathology in AD, and altered cerebral blood flow in AD brains …

Leisure-time physical activity from mid-to late life, body mass index, and risk of dementia

AM Tolppanen, A Solomon, J Kulmala, I Kåreholt… - Alzheimer's & …, 2015 - Elsevier
Anna-Maija Tolppanen and Hilkka Soininen acknowledge financial support by strategic
funding of University of Eastern Finland; Alina Solomon received funding from the Academy of …

Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort

AM Tolppanen, T Ngandu, I Kåreholt… - Journal of …, 2014 - content.iospress.com
Background: Obesity has been consistently associated with dementia. The role of certain
risk factors of dementia may change during life, and the importance of having a life-course …

[HTML][HTML] From prescription drug purchases to drug use periods–a second generation method (PRE2DUP)

…, H Taipale, M Koponen, AM Tolppanen… - BMC medical informatics …, 2015 - Springer
Background Databases of prescription drug purchases are now widely used in
pharmacoepidemiologic studies. Several methods have been used to generate drug use periods …

Global epidemiology of hip fractures: secular trends in incidence rate, post‐fracture treatment, and all‐cause mortality

…, KB Tan, T Thomas, AM Tolppanen… - Journal of Bone and …, 2023 - academic.oup.com
In this international study, we examined the incidence of hip fractures, postfracture treatment,
and all‐cause mortality following hip fractures, based on demographics, geography, and …

Risk Factors for Variation in 25-Hydroxyvitamin D3 and D2 Concentrations and Vitamin D Deficiency in Children

AM Tolppanen, A Fraser, WD Fraser… - The Journal of Clinical …, 2012 - academic.oup.com
Context: Vitamin D status is believed to be best indicated by serum 25-hydroxyvitamin D [25(OH)D;
consisting of 25(OH)D 3 and 25(OH)D 2 ] that are obtained from different sources. …

Postmenopausal hormone therapy and Alzheimer disease: a prospective cohort study

…, M Kivipelto, H Soininen, H Kröger, AM Tolppanen - Neurology, 2017 - AAN Enterprises
Objective: To explore the association between postmenopausal hormone therapy (HT) and
Alzheimer disease (AD). Methods: Twenty-year follow-up data from the Kuopio Osteoporosis …

The Common Variant in the FTO Gene Did Not Modify the Effect of Lifestyle Changes on Body Weight: The Finnish Diabetes Prevention Study

TJ Lappalainen, AM Tolppanen, M Kolehmainen… - …, 2009 - Wiley Online Library
The common single‐nucleotide polymorphism in the FTO (fat mass and obesity associated)
gene is consistently associated with an increased risk of obesity. However, the knowledge of …

[HTML][HTML] Impact of high risk drug use on hospitalization and mortality in older people with and without Alzheimer's disease: a national population cohort study

D Gnjidic, SN Hilmer, S Hartikainen, AM Tolppanen… - PLoS one, 2014 - journals.plos.org
Background Evidence is lacking about outcomes associated with the cumulative use of
anticholinergic and sedative drugs in people with Alzheimer’s disease (AD). This retrospective …