Context The current staging system for chronic kidney disease is based primarily on estimated
glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse …

Objective To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like
peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying …

Background Diabetes is regarded as a coronary heart disease risk equivalent—ie, people
with the disorder have a risk of coronary events similar to those with previous myocardial …

Importance Numerous glucose-lowering drugs are used to treat type 2 diabetes. Objective
To estimate the relative efficacy and safety associated with glucose-lowering drugs including …

Background: Erythropoiesis-stimulating agents are used to treat anemia in patients with
cancer. However, their safety and effectiveness is controversial. We did a systematic review of …

Background: The staging system for chronic kidney disease relies almost exclusively on
estimated glomerular filtration rate (eGFR), although proteinuria is also associated with adverse …

Background: Statins were initially used to improve cardiovascular outcomes in people with
established coronary artery disease, but recently their use has become more common in …

Results After a median follow-up of 35 months, in fully adjusted models and compared with
patients with estimated GFR (eGFR) of 45 to 59 ml/min per 1.73 m 2 and no proteinuria, …

LDL cholesterol (LDL-C) is an important marker of coronary risk in the general population, but
its utility in people with CKD is unclear. We studied 836,060 adults from the Alberta Kidney …

The estimated glomerular filtration rate (eGFR) is a powerful predictor of adverse outcomes,
but most attention has focused on studies in the setting of reduced eGFR. Here we tested …