Note From the Writing Group: Throughout this article, the reader will notice combinations of
superscripted letters and numbers (eg,“Cricoid Pressure ALS-CPR&A-007B”). These callouts …

Purpose: The first-in-human phase I/II ICONIC trial evaluated an investigational inducible
costimulator (ICOS) agonist, vopratelimab, alone and in combination with nivolumab in patients …

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of conditions ranging
from hepatic steatosis to inflammation (nonalcoholic steatohepatitis or NASH) with or without …

Point of care sonography by emergency physicians in the emergency department can be an
effective aid in the diagnosis and management of patients presenting with a variety of …

Background: Peripheral intravenous catheterization in children is challenging, and success
rates vary greatly. We conducted a pragmatic randomized controlled trial to determine …

Factors governing the development of liver fibrosis in nonalcoholic steatohepatitis (NASH)
are only partially understood. We recently identified adipocyte enhancer binding protein 1 (…

Immunotherapy checkpoint inhibitors, such as antibodies targeting PD-1 and CTLA-4, have
demonstrated the potential of harnessing the immune system to treat cancer. However, …

T lymphocytes require signals from self-peptides and cytokines, most notably interleukins 7
and 15 (IL-7, IL-15), for survival. While mouse T cells die rapidly if IL-7 or IL-15 is withdrawn, …

CCL20 (CC chemokine ligand 20) is emerging as an important regulatory molecule in a
pathway common to virus infection, alcoholic hepatitis, and non-alcoholic fatty liver disease (…

Background Early ocean experience is a critical time period that affects juvenile salmonid
survival. Understanding juvenile salmonid behavior in nearshore marine environments and …