Background People who are prescribed self administered medications typically take only
about half their prescribed doses. Efforts to assist patients with adherence to medications might …

Accurate information regarding prognosis is fundamental to optimal clinical care. The best
approach to assess patient prognosis relies on prediction models that simultaneously …

Objective To clarify the grading of recommendations assessment, development and evaluation
(GRADE) definition of certainty of evidence and suggest possible approaches to rating …

Background The optimal duration of oral anticoagulation in patients with idiopathic venous
thromboembolism is uncertain. Testing of d-dimer levels may play a role in the assessment of …

Background In patients with idiopathic deep venous thrombosis, continuing anticoagulant
therapy beyond three months is associated with a reduced incidence of recurrent thrombosis …

Methods In developing this guideline, the steering committee followed standards for trustworthy
guidelines. 15 We included innovative approaches for key standards such as patient …

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness.
Analysis of disease tolerance pathways could provide new approaches for treating infections …

Background Compression stockings are recommended for prophylaxis against venous
thromboembolism in patients undergoing neurosurgery, but anticoagulant agents have not …

The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE)
approach defines quality of evidence as confidence in effect estimates; this conceptualization …

Background— The aim of this study was to estimate the impact of thrombophilia on risk of first
childhood stroke through a meta-analysis of published observational studies. Methods and …