Background: The role of remdesivir in the treatment of patients in hospital with COVID-19
remains ill defined in a global context. The World Health Organization Solidarity randomized …

Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges,
some of which will lead to transformative change. It is obvious to healthcare workers and …

Reconstruction of a gene with its introns removed results in reduced levels of cytoplasmic
mRNA. This is partly explained by introns promoting the export of mRNA through coupling …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Background Breast cancer is a highly heterogeneous disease resulting in diverse clinical
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is …

Intensive care unit healthcare workers (ICU HCW) are at risk of mental health issues during
emerging disease outbreaks. A study of ICU HCW from France revealed symptoms of anxiety …

This article summarizes the current status of ARDS biomarker research and provides a
framework for future investigation.

Objectives: Recent evidence from the fields of microbiology and immunology, as well as a
small number of human sepsis studies, suggest that epigenetic regulation may play a central …

Objectives: Epigenetic alterations are an important regulator of gene expression in health
and disease; however, epigenetic data in sepsis are lacking. To demonstrate proof of concept …

Importance Blood collection for laboratory testing in intensive care unit (ICU) patients is a
modifiable contributor to anemia and red blood cell (RBC) transfusion. Most blood withdrawn is …