Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

Background Non-selective, non-steroidal anti-inflammatory drugs (NSAIDs) are associated
with an increased risk of congestive heart failure, but little is known about the cardiovascular …

Introduction: Opioid-related mortality appears to be increasing in Canada. We examined the
true extent of the problem and the impact of the introduction of long-acting oxycodone. …

Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …

BACKGROUND: Globally, primary care changed dramatically as a result of the coronavirus
disease 2019 (COVID-19) pandemic. We aimed to understand the degree to which office and …

Objective: To compare rates of upper gastrointestinal haemorrhage among elderly patients
given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-…

Background Recent debate has emerged regarding the cardiovascular safety of selective
cyclooxygenase 2 inhibitors and the possible cardioprotective effect of naproxen sodium. We …

ContextDrug-drug interactions are a preventable cause of morbidity and mortality, yet their
consequences in the community are not well characterized.ObjectiveTo determine whether …

Background Emerging evidence suggests that living near major roads might adversely
affect cognition. However, little is known about its relationship with the incidence of dementia, …

Background Suicide is a leading cause of death, and rates are especially high among the
elderly. Medical illnesses may predispose to suicide, but few controlled studies have …