Background Computed tomography (CT) must be done before thrombolytic treatment of
hyperacute ischaemic stroke, but the significance of early ischaemic change on CT is unclear. …

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …

Increases in brain blood flow, evoked by neuronal activity, power neural computation and
form the basis of BOLD (blood-oxygen-level-dependent) functional imaging. Whether blood …

BACKGROUND AND PURPOSE: Clinicians are insecure reading CT scans by using the
one-third rule for acute middle cerebral artery stroke (1/3 MCA rule) before treating patients with …

Background Patients with transient ischaemic attack (TIA) or minor stroke are at high
immediate risk of stroke. The optimum early treatment options for these patients are not known. …

Background: Thrombolysis for acute ischemic stroke has remained controversial. The
Canadian Alteplase for Stroke Effectiveness Study, a national prospective cohort study, was …

Background and Purpose—Five pretreatment variables (P<0.1 univariate analysis), including
serum glucose (>300 mg/dL), predicted symptomatic intracerebral hemorrhage (ICH) in the …

Intracerebral haemorrhage (ICH) is the most devastating type of stroke and is a leading
cause of disability and mortality. By contrast with advances in ischaemic stroke treatment, few …

Laddered DNA indicative of apoptosis was observed in the CA1 layer of hippocampus and
in dorsolateral striatum following a global cerebral ischemic insult produced by transient two …

Reperfusion therapy with tissue plasminogen activator (tPA) is a rational therapy for acute
ischemic stroke. Properly titrated use of tPA improves clinical outcomes. However, there is …