User profiles for Aaron E. Lin
 | Aaron E. LinPostdoctoral fellow, Princeton University Verified email at princeton.edu Cited by 3174 |
[PDF][PDF] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
…, SA Quinodoz, C Loney, J Thai, ZD Miller, AE Lin… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19)…
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19)…
Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
INTRODUCTION We used genomic epidemiology to investigate the introduction and spread
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Boston area …
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Boston area …
Zika virus evolution and spread in the Americas
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …
[HTML][HTML] Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone
The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of
Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus …
Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus …
[PDF][PDF] Programmable inhibition and detection of RNA viruses using Cas13
The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA)
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA)…
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA)…
[HTML][HTML] Clinical sequencing uncovers origins and evolution of Lassa virus
…, BJ Shapiro, CB Matranga, R Sealfon, AE Lin… - Cell, 2015 - cell.com
The 2013–2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little
is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause …
is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause …
[HTML][HTML] Ebola virus glycoprotein with increased infectivity dominated the 2013–2016 epidemic
The magnitude of the 2013–2016 Ebola virus disease (EVD) epidemic enabled an
unprecedented number of viral mutations to occur over successive human-to-human transmission …
unprecedented number of viral mutations to occur over successive human-to-human transmission …
[HTML][HTML] Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time
Recent outbreaks of viral hemorrhagic fevers (VHFs), including Ebola virus disease (EVD)
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …
[PDF][PDF] Single-cell profiling of Ebola virus disease in vivo reveals viral and host dynamics
Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to
the challenge of experimentation in high-containment and outbreak settings. Here, we used …
the challenge of experimentation in high-containment and outbreak settings. Here, we used …
[HTML][HTML] Capturing sequence diversity in metagenomes with comprehensive and scalable probe design
Metagenomic sequencing has the potential to transform microbial detection and
characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a …
characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a …