User profiles for Aaron D. Schimmer

aaron schimmer

Verified email at uhn.ca
Cited by 22399

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

…, JM Brandwein, V Gupta, JA Kennedy, AD Schimmer… - Nature, 2014 - nature.com
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of
initiating lesions, and order of subsequent mutations remain poorly understood, as AML is …

A 17-gene stemness score for rapid determination of risk in acute leukaemia

…, A Arruda, A Popescu, V Gupta, AD Schimmer… - Nature, 2016 - nature.com
Refractoriness to induction chemotherapy and relapse after achievement of remission are
the main obstacles to cure in acute myeloid leukaemia (AML) 1 . After standard induction …

Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice

AD Schimmer - Cancer research, 2004 - AACR
The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and
inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs …

Anoikis resistance and tumor metastasis

CD Simpson, K Anyiwe, AD Schimmer - Cancer letters, 2008 - Elsevier
As a barrier to metastases, cells normally undergo apoptosis after they lose contact with their
extra cellular matrix or their neighbouring cells. This cell death process has been termed “…

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.

…, K Humphries, C Nislow, G Giaever, AD Schimmer - Cancer cell, 2011 - europepmc.org
To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen
on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-…

[PDF][PDF] Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

AD Schimmer, K Welsh, C Pinilla, Z Wang… - Cancer cell, 2004 - cell.com
Apoptosis resistance commonly occurs in cancers, preventing activation of Caspase family
cell death proteases. XIAP is an endogenous inhibitor of Caspases overexpressed in many …

Myelodysplastic syndromes: the complexity of stem-cell diseases

…, H Kantarjian, JCY Wang, AD Schimmer - Nature Reviews …, 2007 - nature.com
The prevalence of patients with myelodysplastic syndromes (MDS) is increasing owing to
an ageing population and increased awareness of these diseases. MDS represent many …

[PDF][PDF] Inhibition of the mitochondrial protease ClpP as a therapeutic strategy for human acute myeloid leukemia

…, Z Hao, SM Kornblau, B Raught, AD Schimmer - Cancer cell, 2015 - cell.com
From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose
knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial …

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

…, JE Dick, MD Minden, AD Schimmer - Blood, The Journal …, 2015 - ashpublications.org
Mitochondrial respiration is a crucial component of cellular metabolism that can become
dysregulated in cancer. Compared with normal hematopoietic cells, acute myeloid leukemia (…

Novel proteasome inhibitors to overcome bortezomib resistance

…, M Slassi, LE Kay, AD Schimmer - Journal of the National …, 2011 - academic.oup.com
The proteasome is an intracellular enzyme complex that degrades ubiquitin-tagged proteins
and thereby regulates protein levels within the cell. Given this important role in maintaining …