Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain
Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical …

Objective. To provide recommendations for the core outcome domains that should be considered
by investigators conducting clinical trials of the efficacy and effectiveness of treatments …

It has been suggested that the quality of clinical trials should be assessed by blinded raters
to limit the risk of introducing bias into meta-analyses and systematic reviews, and into the …

Background Few meta-analyses of randomised trials assess the quality of the studies
included. Yet there is increasing evidence that trial quality can affect estimates of intervention …

The WHO definition of health as complete wellbeing is no longer fit for purpose given the
rise of chronic disease. Machteld Huber and colleagues propose changing the emphasis …

… Jadad-Bechara AR. Meta-Analysis of randomised clinical trials in pain relief. DPhil thesis,
University of Oxford, 1994. (Paper in preparation by Jadad AR, Moore RA, Carroll D, …

Context.—The rapid growth of the Internet has triggered an information revolution of
unprecedented magnitude. Despite its obvious benefits, the increase in the availability of …

Objective: To determine effectiveness and adverse effects of anticonvulsant drugs in management
of pain. Design: Systematic review of randomised controlled trials of anticonvulsants …

The book’s subtitle sets the tone. Born of the author’s struggle to find, understand, interpret,
and use randomised controlled trials, this book is the fruit of years of jotting down questions …