Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the central …

The drive for higher performance in optical fiber systems has renewed interest in coherent
detection. We review detection methods, including noncoherent, differentially coherent, and …

Using the research framework recommended by L. Rogler, R. Malgady, and D. Rodriguez (1989),
the current paper examines the barriers to providing effective mental health services to …

Tumor genetics guides patient selection for many new therapies, and cell culture studies
have demonstrated that specific mutations can promote metabolic phenotypes. However, …

Metastasis is the leading cause of morbidity for lung cancer patients. Here we demonstrate
that murine tumor propagating cells ( TPC s) with the markers S ca1 and CD 24 are enriched …

Background The inhibition of poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP)
is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes
that define cell identity. Improved understanding of the roles that super-enhancers play in …

Chromatin regulators have become attractive targets for cancer therapy, but it is unclear
why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. …

Dietary interventions can change metabolite levels in the tumour microenvironment, which
might then affect cancer cell metabolism to alter tumour growth 1 , 2 , 3 , 4 – 5 . Although …

Defining the metabolic limitations of tumour growth will help to develop cancer therapies 1 .
Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that …