A mathematic model has been developed relating the drug sensitivity of a tumor to its own
spontaneous mutation rate towards phenotypic drug resistance. The proportion as well as the …

Background Radiotherapy after mastectomy to treat early breast cancer has been known
since the 1940s to reduce rates of local relapse. However, the routine use of postoperative …

Background: The British Columbia randomized radiation trial was designed to determine
the survival impact of locoregional radiation therapy in premenopausal patients with lymph …

Background and Design: Basal cell carcinoma (BCC) of the skin is the most common
neoplasm in white populations, and solar radiation is generally accepted to be the dominant …

Purpose Adjuvant! ( www.adjuvantonline.com ) is a web-based tool that predicts 10-year
breast cancer outcomes with and without adjuvant systemic therapy, but it has not been …

… Coldman, AJ, and Goldie, JH A model for the resistance of lumor cells to cancer … Goldie,
JH, and Coldman, AJ Quantitative model for multiple levels of drug resistance in clinical tumors. …

In this paper an argument is presented for examining the rationale for the use of alternating
non-cross-resistant chemotherapy. It is assumed that the development of a doubly resistant …

: The evaluation of cancer pain remains a problematic clinical problem, not only due to the
subjective and multidimensional nature of pain per se, but also because of its specific …

The prognostic significance of Bcl-2 protein expression and bcl-2 gene rearrangement in
diffuse large cell lymphomas (DLCL) is controversial. Bcl-2 protein expression prevents …

Introduction and Design: Squamous cell carcinoma of the skin (SCC), a common cancer in
white populations, is related to sunshine exposure; however, relatively little information is …