Although caffeine is the most widely used behaviorally active drug in the world, caffeine
physical dependence has been poorly characterized in laboratory animals and only …

Pain and discomfort in everyday life are often treated with over-the-counter (OTC) analgesic
medications. These drugs are remarkably safe, but serious side effects can occur. Up to 70 …

To examine the use of analgesics as a cause of chronic renal disease, we performed a
multicenter case–control study of 554 adults with newly diagnosed kidney disease (serum …

Acetaminophen in acute overdose is primarily recognized as potentially hepatotoxic with few
descriptions of extrahepatic lesions other than nephrotoxicity. Fasted adult, male mice, both …

The weight of clinical evidence linking analgesic abuse with chronic renal disease is
overwhelming and analgesic nephropathy continues to be an important problem. The …

This paper reviews the literature and presents some new data on alcohol and drug problems
in older individuals. Drug abusers include users of opiates (5% of opiate addicts are over …

Twenty-two patients with renal disease seen over a 4-year period had abused analgesics
containing acetylsalicylic acid, phenacetin, caffeine, and in all but one instance codeine. The …

Nearly half the rats gavage-fed with aspirin and aspirin-containing mixtures developed
papillary necrosis in 20 weeks. This incidence is similar to that found in rats on APC mixtures …

Background Unusual resistance to treatment in 5% to 7% of 1,845 peptic ulcers examined
under endoscopy from 1987 to 1996 prompted a search for unusual causes. Although some …

The original suggestion that an association exists between the ingestion of large amounts of
analgesics and the development of interstitial nephropathy was made in 1953 [1]. Since that …