Approximately one-third of individuals in a major depressive episode will not achieve
sustained remission despite multiple, well-delivered treatments. These patients experience …

Epilepsy is a brain disease characterized by abnormal electrical activity causing seizures or
unusual behaviour, sensations and sometimes loss of awareness. It carries neurological …

Neurological disorders pose a large burden on worldwide health. The most recent estimates
show that the neurological disorders included in the Global Burden of Disease (GBD) Study …

Electroencephalogram (EEG) is one of the main diagnostic tests for epilepsy. The detection
of epileptic activity is usually performed by a human expert and is based on finding specific …

Over 15 million patients with epilepsy worldwide do not respond to drugs. Successful
surgical treatment requires complete removal or disconnection of the seizure onset zone …

Objective Vagus nerve stimulation (VNS) is a common treatment for medically intractable
epilepsy, but response rates are highly variable, with no preoperative means of identifying …

Objectives Residual fast ripples (FR) in the intraoperative ECoG are highly specific
predictors of postsurgical seizure recurrence. However, a FR is generated by a small patch …

Previously, we demonstrated the efficacy of human pluripotent stem cell (hPSC)-derived
GABAergic cortical interneuron (cIN) grafts in ameliorating seizures. However, a safe and …

Current drug treatments for epilepsy attempt to broadly restrict excitability to mask a
symptom, seizures, with little regard for the heterogeneous mechanisms that underlie …

To achieve seizure freedom, epilepsy surgery requires the complete resection of the
epileptogenic brain tissue. In intraoperative electrocorticography (ECoG) recordings, high …