Fibrinogen plays a critical role in achieving and maintaining hemostasis and is fundamental
to effective clot formation. There is increasing awareness of the important role of fibrinogen …

Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Background Acute blood loss in trauma requires quick identification and action to restore
circulating volume and save the patient. Massive transfusion protocols (MTPs) have become …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Background The resuscitation of severely injured bleeding patients has evolved into a multi-
modal strategy termed damage control resuscitation (DCR). This guideline evaluates …

Background Plasma is integral to haemostatic resuscitation after injury, but the timing of
administration remains controversial. Anticipating approval of lyophilised plasma by the US …

Purpose To develop evidence-based clinical practice recommendations regarding
transfusion practices and transfusion in bleeding critically ill adults. Methods A taskforce …

Background Major haemorrhage is a clinical emergency that results in morbidity and
mortality: practice guidance is important to reduce these risks. Delayed recognition of …

Trauma promotes trauma‐induced coagulopathy, which requires urgent treatment with fixed‐
ratio transfusions of red blood cells, fresh frozen plasma and platelet concentrates, or goal …