Physiological Approach to Assessment of Acid–Base Disturbances | NEJM Skip to main content
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The kidney has the principal role in the maintenance of acid-base balance, and therefore, a
fall in renal net acid excretion and positive H+ balance often leading to reduced serum [HCO …

Metabolic acidosis is not uncommon in CKD and is linked with bone demineralization,
muscle catabolism, and higher risks of CKD progression and mortality. Clinical practice …

Background Low serum bicarbonate concentration is a risk factor for death in people with
chronic kidney disease (CKD). Whether low serum bicarbonate is a mortality risk factor for …

Results The mean age was 76 years, 51% were women, and 38% were black. Mean pH was
7.41, mean bicarbonate was 25.1 mEq/L, 11% had low bicarbonate, and 10% had high …

Purpose Anion gap (AG) is a valuable and easily obtained clinical tool for differentially
diagnosis of acid-base disorders. Current understanding of the prognostic impact of AG on …

Acid retention associated with reduced glomerular filtration rate (GFR) exacerbates
nephropathy progression in partial nephrectomy models of chronic kidney disease (CKD) …

Background: Normal anion gap metabolic acidosis is a common but often misdiagnosed
clinical condition associated with diarrhea and renal tubular acidosis (RTA). Early …

Background: Several biomarkers of metabolic acidosis, including lower plasma bicarbonate
and higher anion gap, have been associated with greater insulin resistance in cross …

Metabolic acidosis affects about 15% of patients with chronic kidney disease. As kidney
function declines, the kidneys progressively fail to eliminate acid, primarily reflected by a …