Background Questions concerning the safety of selective serotonin reuptake inhibitors
(SSRIs) in the treatment of depression in children led us to compare and contrast published …

This book provides a comprehensive review of melancholia as a severe disorder of mood,
associated with suicide, psychosis, and catatonia. The syndrome is defined with a clear …

Do antidepressants work? Of course everyone knows it. Like his colleagues, Irving Kirsch, a
researcher and clinical psychologist, for years referred patients to psychiatrists to have their …

Following the FDA black box warning in 2004, substantial reductions in antidepressant
(ATD) use were observed within 2 years in children and adolescents in several countries …

Take the case of Dr. Joseph L. Biederman, professor of psychiatry at Harvard Medical
School and chief of pediatric psychopharmacology at Harvard's Massachusetts General …

Industry-Sponsored Clinical Research: A Broken System ing compliance and good will. The
new policies lose their controversial character rather quickly. The faculty moves on—and this …

Drawing on narrative interviews with psychiatrists and health analysts in Britain, the article
provides an analysis of debates over the safety of SSRI antidepressants such as Prozac and …

Objective: The authors explored the relationship between the initiation of therapy with
selective serotonin reuptake inhibitor (SSRI) antidepressants and completed suicide in older …

IN A RECENT ARTICLE IN JAMA ON THE REGISTRATION OF clinical trials, 1 Dickersin and
I pointed out that, 30 years after the idea of registering trials had been proposed, 18 years …

Medicine is supposed to make progress, to go forward in scientific terms so that each
successive generation knows more and does better than previous generations. This hasn't …