Mechanisms of atrial fibrillation: lessons from animal models

S Nattel, A Shiroshita-Takeshita, BJJM Brundel… - Progress in …, 2005 - Elsevier
Studies in animal models have provided extremely important insights about atrial fibrillation
(AF). The classic mechanisms that still form the framework for our understanding of AF (focal …

Atrial fibrillation: basic mechanisms, remodeling and triggers

A Shiroshita-Takeshita, BJJM Brundel… - Journal of Interventional …, 2005 - Springer
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Inflammation effects on the electrical properties of atrial tissue and inducibility of postoperative atrial fibrillation

EV Tselentakis, E Woodford, J Chandy… - Journal of Surgical …, 2006 - Elsevier
BACKGROUND: Atrial fibrillation is the most common complication after cardiac surgery.
Postoperative atrial fibrillation (PAF) has been shown to increase length of stay, morbidity …

Digoxin and mortality in atrial fibrillation: a prospective cohort study

P Hallberg, J Lindbäck, B Lindahl… - European journal of …, 2007 - Springer
Abstract Objective The Atrial Fibrillation Follow-up Investigation of Rhythm Management
(AFFIRM) study showed that rhythm-control treatment of patients with atrial fibrillation (AF) …

Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation

L Ke, XY Qi, AJ Dijkhuis, D Chartier, S Nattel… - Journal of molecular and …, 2008 - Elsevier
The self-perpetuation of atrial fibrillation (AF) is associated with atrial remodeling, including
the degradation of the myofibril structure (myolysis). Myolysis is related to AF-induced …

The role of ascorbic acid in the prevention of atrial fibrillation after elective on-pump myocardial revascularization surgery: a single-center experience–a pilot study

P Papoulidis, O Ananiadou… - … and thoracic surgery, 2011 - academic.oup.com
Atrial fibrillation (AF) is a common arrhythmia that occurs postoperatively in cardiac surgery.
There is evidence for the role of oxidative stress in the etiology of AF. In our study, we …

Women with atrial fibrillation: greater risk, less attention

AS Volgman, MF Manankil, D Mookherjee… - Gender medicine, 2009 - Elsevier
Background: In 1995, atrial fibrillation (AF) was estimated to affect 2.2 million people in the
United States. After the age of 75 years (the median age for onset of AF),~ 60% of people …

Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing‐induced left ventricular dysfunction

M Sakabe, A Fujiki, T Sakamoto… - Journal of …, 2012 - Wiley Online Library
Allopurinol and Atrial Fibrillation. Aims: Oxidative stress could be a possible mechanism and
a therapeutic target of atrial fibrillation (AF). Xanthine oxidase (XO) inhibition reduces …

Improving the outcomes of anticoagulation: an evaluation of home follow‐up of warfarin initiation

SL Jackson, GM Peterson, JH Vial… - Journal of internal …, 2004 - Wiley Online Library
Objectives. A number of studies have reported that the risk of bleeding associated with
warfarin is highest early in the course of therapy. This study examined the effect of a …

Effects of chronic atrial fibrillation on active and passive force generation in human atrial myofibrils

A Belus, N Piroddi, C Ferrantini, C Tesi… - Circulation …, 2010 - Am Heart Assoc
Rationale: Chronic atrial fibrillation (cAF) is associated with atrial contractile dysfunction.
Sarcomere remodeling may contribute to this contractile disorder. Objective: Here, we use …