One hundred years ago, in August of 1914, during the first month of World War I, a group of
French soldiers attacked German troops and, for the first time in declared warfare, used …

Since 2010, three novel oral anticoagulants have been approved in the United States and in
Europe, opening up the range of therapeutic options for patients at risk of dangerous blood …

One hundred years ago, in August of 1914, during the first month of World War I, a group of
French soldiers attacked German troops and, for the first time in declared warfare, used …

Highlights•Until now warfarin was the most described oral anticoagulant.•The new oral
anticoagulants affect different steps in the coagulation cascade and simplify long-term …

Oral anticoagulants or 'blood thinners' were proposed in 400 BC during the time of
Hippocrates [1]. The first paper entitled 'Coumadin (warfarin) sodium–a new …

Any substance which prevents blood from clotting or prolongs the clotting time is called an
anticoagulant. Some of them are isolated from natural sources like heparin, hirudin, anti …

During more than 60 years, the only option for oral anticoagulation was warfarin and its
derivatives. Despite its efficacy, its management remains troublesome due to special …

The most commonly prescribed oral anticoagulants worldwide are the vitamin K antagonists
(VKAs) such as warfarin. Factors affecting the pharmacokinetics of VKAs are important …

The chemical warfare agent was a 20th century military name used to describe a chemical
compound that could be used to injure or kill opposing forces on the battlefield. The list of …

It is rare for any drug introduced more than 50 years ago to remain unsurpassed today; yet
the oral prevention and treatment of thrombosis are still achieved by the use of the vitamin K …