IT IS now well established that chronic treatment with GnRH agonists offers an advantageous
alternative to orchiectomy and estrogens for the treatment of prostate cancer. Castration …

ContextHypertensive patients are often given a calcium antagonist to reduce cardiovascular
disease risk, but the benefit compared with other drug classes is controversial.ObjectiveTo …

Background Endothelin is a powerful vasoconstrictor peptide derived from the endothelium.
We evaluated the contribution of endothelin to blood-pressure regulation in patients with …

Background LCZ696 is a first-in-class inhibitor of the angiotensin II receptor and neprilysin.
We aimed to establish whether the dual actions of LCZ696 lead to further lowering of blood …

… The role of β-blockers was also reviewed recently by Poirier and Lacourcière, who concluded
that although β-blockers are clearly effective in reducing BP, the mechanism of action of …

In order to block the influence of androgens from all sources on the growth of prostatic cancer,
we have used a new hormonal therapy based on medical castration achieved with the …

Background Diastolic dysfunction might represent an important pathophysiological intermediate
between hypertension and heart failure. Our aim was to determine whether inhibitors of …

Background— Elevated pulse pressure (PP) is associated with increased cardiovascular risk
and is thought to be secondary to elastin fragmentation with secondary collagen deposition …

Several studies have indicated that a single bout of physical exercise induced a significant
antihypertensive effect during the hours after the activity. However, little information is …

… Data from Lacourcière et al 7 and Chan et al 18 were used for the power calculation. The
calculation was carried out on the variable defined as LOG 10 (UAE at exit/UAE at baseline). …