We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes
subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α …

Background: Temporal trends in risk factors for cardiovascular disease and the impact of
socio-economic status on these risk factors remain unclear. Methods: Using data from the …

Background Computer simulation models are used increasingly to support public health
research and policy, but questions about their quality persist. The purpose of this article is to …

Importance The US National Lung Screening Trial supports screening for lung cancer among
smokers using low-dose computed tomographic (LDCT) scans. The cost-effectiveness of …

This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key
SAR and critical binding elements are discussed. Some of the more advanced analogues …

Background Guidelines recommend low-dose CT (LDCT) screening to detect lung cancer
among eligible at-risk individuals. We used the OncoSim model (formerly Cancer Risk …

The POpulation HEalth Model (POHEM) is a health microsimulation model that was developed
at Statistics Canada in the early 1990s. POHEM draws together rich multivariate data …

Objectives. To estimate the risk of work loss due to illness or disability in a cohort of employed
persons with OA compared with matched non-OA individuals. Methods. We performed a …

Background: Low-dose computed tomography (CT) screening can reduce lung cancer mortality
in people at high risk; adding a smoking cessation intervention to screening could further …

Objective Prevalence of osteoarthritis (OA) is expected to increase due to population aging.
However, there is little information on the trends in the incidence of OA over time. The …