Background: In vitro data suggest that lower extracellular pH activates the immune system.
We conducted a population-based study of the relation between serum acid–base status …

Increased production of organic acid can result in an elevated serum anion gap and may
play a role in the development of hypertension. We studied the cross-sectional associations …

Background Obesity is associated with low serum bicarbonate, an indicator of metabolic
acidosis and a CKD risk factor. To further characterize acid-base disturbance and subclinical …

Results The mean serum bicarbonate was 24.9 mEq/L (SEM= 0.1), and the mean estimated
net endogenous acid production was 57.4 mEq/d (SEM= 0.4). Serum bicarbonate was …

Although metabolic acid load has been associated with many well-known risk factors for
mortality, its clinical implications are not yet clear. To evaluate the association between …

Objective In chronic kidney disease (CKD), dietary acid may promote metabolic acidosis and
insulin resistance, which in turn may contribute to adverse clinical health outcomes. We …

Prevalence of acidosis and inflammation and their association with low serum albumin in
chronic kidney disease. Background Low serum albumin is a strong risk factor for mortality …

BACKGROUND Several biomarkers of metabolic acidosis, including lower plasma
bicarbonate, have been associated with prevalent hypertension in cross-sectional studies …

Aims Metabolic acidosis may contribute to the development of insulin resistance. To date,
there have been no population‐based studies of acid‐base status and insulin resistance …

Rationale & Objective Patients with CKD are at elevated risk of metabolic acidosis due to
impaired net acid excretion (NAE). Identifying early markers of acidosis may guide …