Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/neu Oncogene

DJ Slamon, GM Clark, SG Wong, WJ Levin, A Ullrich… - science, 1987 - science.org
The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to,
but distinct from, the epidermal growth factor receptor. This gene has been shown to be …

Studies of the HER-2/neu Proto-Oncogene in Human Breast and Ovarian Cancer

…, LA Jones, JA Holt, SG Wong, DE Keith, WJ Levin… - Science, 1989 - science.org
Carcinoma of the breast and ovary account for one-third of all cancers occurring in women
and together are responsible for approximately one-quarter of cancer-related deaths in …

Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic …

…, P He, N Angra, AK Gupta, W Levin… - The Lancet …, 2020 - thelancet.com
Background Survival outcomes are poor for patients with metastatic urothelial carcinoma
who receive standard, first-line, platinum-based chemotherapy. We assessed the overall …

Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies

…, BH Simmons, J Lippincott, GF Casperson, WJ Levin… - Cancer research, 2011 - AACR
Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1) plays an
important role in vascular development, remodeling, and pathologic angiogenesis. Here we …

Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study

…, M Baccarani, HM Kantarjian, WJ Levin… - The Lancet …, 2015 - thelancet.com
Background Activation of the Hedgehog signalling pathway contributes to cancer progression
and the development of myeloid leukaemia stem cell therapeutic resistance. We aimed to …

Expression patterns of immediate early transcription factors in human non-small cell lung cancer. The Lung Cancer Study Group.

WJ Levin, MF Press, RB Gaynor, VP Sukhatme… - Oncogene, 1995 - europepmc.org
In 1995, there will be 172,000 new cases of lung cancer diagnosed and 153,000 deaths from
this disease in the United States. While the pathogenesis of the disease process is poorly …

Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology

…, LJ Helman, MB Kastan, DW Knapp, WJ Levin… - Science translational …, 2016 - science.org
Levin, Cheryl London, Nicola Mason, Christina Mazcko, Patricia N. Olson, Rodney Page,
Beverly A. Teicher, Douglas H. … Wendy J. Levin

A phase I study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors

…, KR McLachlan, R Cesari, R Courtney, WJ Levin… - Clinical Cancer …, 2015 - AACR
Purpose: To estimate the maximum tolerated dose (MTD) of single-agent PF-04449913,
and to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary …

[HTML][HTML] Validity of the international physical activity questionnaire short form (IPAQ-SF) as a measure of physical activity (PA) in young people with cerebral palsy: A …

…, C Kilbride, V Baltzopoulos, A Shortland, W Levin… - Physiotherapy, 2020 - Elsevier
Objectives The aim of this study was to examine the validity of the International Physical
Activity Questionnaire Short Form (IPAQ-SF) as a measure of physical activity (PA) in young …

Progressive resistance training for adolescents with cerebral palsy: the STAR randomized controlled trial

…, V Baltzopoulos, A Shortland, W Levin… - … Medicine & Child …, 2020 - Wiley Online Library
Aim To evaluate the effect of progressive resistance training of the ankle plantarflexors on gait
efficiency, activity, and participation in adolescents with cerebral palsy (CP). Method Sixty‐…