Background Tuberous sclerosis complex is highly variable in clinical presentation and
findings. Disease manifestations continue to develop over the lifetime of an affected individual. …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are
devastating brain tumors with no effective therapy. Here, we investigated clinical and biological …

Background Tuberous sclerosis complex is a genetic disorder affecting every organ system,
but disease manifestations vary significantly among affected individuals. The diverse and …

Diffuse intrinsic brainstem gliomas constitute 15–20% of all CNS tumours in children, and are
the main cause of death in children with brain tumours. Many clinical trials have been done …

Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease
affecting multiple body systems with wide variability in presentation. In 2013, Pediatric …

Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of
children, with no effective treatment and near 100% fatality. The failure of most therapies can …

Purpose Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of pediatric
malignancies and one for which no effective therapy exists. A major contributor to the failure of …

Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median
survival of < 1 year. The International and European Society for Pediatric Oncology DIPG …

The development of targeted anti-cancer therapies through the study of cancer genomes is
intended to increase survival rates and decrease treatment-related toxicity. We treated a …