Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma.
As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected …
As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected …
The effect of age and duration of disease on airway structure in fatal asthma
We hypothesized that if airway remodeling is related to duration of asthma, that when matched
for severity, the airways of older adults should show greater alterations than the airways …
for severity, the airways of older adults should show greater alterations than the airways …
Inflammation of small airways in asthma
…, Y Song, TC Kotsimbos, E Minshall, TR Bai… - Journal of Allergy and …, 1997 - Elsevier
This study was designed to examine the inflammatory process in the central and peripheral
airways of surgically resected lungs from asthmatic and nonasthmatic subjects. Lung …
airways of surgically resected lungs from asthmatic and nonasthmatic subjects. Lung …
Small airways dimensions in asthma and in chronic obstructive pulmonary disease
K Kuwano, CH Bosken, PD Paré, TR Bai… - American Review of …, 1993 - atsjournals.org
The purpose of this study was to compare the dimensions of the peripheral airways in fatal
asthma with those from patients with nonfatal asthma, mild COPD, and normal lung function. …
asthma with those from patients with nonfatal asthma, mild COPD, and normal lung function. …
Induction of epithelial–mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1
Rationale: Airway remodeling in asthma is associated with the accumulation of fibroblasts,
the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The …
the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The …
Structural changes in the airways in asthma: observations and consequences
TR Bai, DA Knight - Clinical science, 2005 - portlandpress.com
Structural changes reported in the airways of asthmatics include epithelial fragility, goblet
cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix …
cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix …
Characterization of airway plugging in fatal asthma
…, RK Lambert, D Ionescu, R Woods, TR Bai - The American journal of …, 2003 - Elsevier
PURPOSE: Case reports suggest that deaths due to asthma can occur without airway
plugging. In this study, we examined the hypothesis that obstruction of the airway lumen by an …
plugging. In this study, we examined the hypothesis that obstruction of the airway lumen by an …
Airway smooth muscle hypertrophy and hyperplasia in asthma
…, RL Jones, ML Carroll, T Mauad, TR Bai… - American journal of …, 2012 - atsjournals.org
Rationale: Increased thickness of the airway smooth muscle (ASM) layer in asthma may result
from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). …
from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). …
Risk factors for near-fatal asthma: a case–control study in hospitalized patients with asthma
MO Turner, K Noertjojo, S Vedal, T Bai… - American journal of …, 1998 - atsjournals.org
We prospectively recruited patients admitted to the hospital with severe asthma to comprehensively
evaluate the association of historical and physiologic features with the risk of near-…
evaluate the association of historical and physiologic features with the risk of near-…
Abnormalities in Airway Smooth Muscle in Fatal Asthma1-3
TR Bai - Am Rev Respir Dis, 1990 - atsjournals.org
The characteristics of asthmatic alrwBy smooth muscle are poorly described. Using standard
organ bath techniques, the In vitro Isometric contractile and relaxant responses of tracheal …
organ bath techniques, the In vitro Isometric contractile and relaxant responses of tracheal …
