ContextCurrent evidence that breastfeeding is beneficial for infant and child health is based
exclusively on observational studies. Potential sources of bias in such studies have led to …

Background: Chronic neuropathic pain affects 1%–2% of the adult population and is often
refractory to standard pharmacologic treatment. Patients with chronic pain have reported using …

Context The evidence that breastfeeding improves cognitive development is based almost
entirely on observational studies and is thus prone to confounding by subtle behavioral …

Background Maternal age at pregnancy is increasing worldwide as well as preterm birth.
However, the association between prematurity and advanced maternal age remains …

Background The optimal hemoglobin threshold for erythrocyte transfusions in critically ill
children is unknown. We hypothesized that a restrictive transfusion strategy of using packed red …

Background: The reason some patients with deep venous thrombosis (DVT) develop the
postthrombotic syndrome is not well understood. Objective: To determine the frequency, time …

Objectives To investigate the relation between the risk of Alzheimer’s disease and exposure
to benzodiazepines started at least five years before, considering both the dose-response …

Background Post-thrombotic syndrome (PTS) is a common and burdensome complication
of deep venous thrombosis (DVT). Previous trials suggesting benefit of elastic compression …

Background Opinions and recommendations about the optimal duration of exclusive breastfeeding
have been strongly divided, but few published studies have provided direct evidence …

Introduction In adults, small (< 50%) serum creatinine (SCr) increases predict mortality. It is
unclear whether different baseline serum creatinine (bSCr) estimation methods affect findings …