Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. …

The 2017 update of The Canadian Stroke Best Practice Recommendations for the Secondary
Prevention of Stroke is a collection of current evidence-based recommendations intended …

Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis,
assessment, prevention, and treatment of hypertension in adults and children. This year, …

Background: Pain is a common complication after stroke and is associated with the
presence of depression, cognitive dysfunction, and impaired quality of life. It remains …

Importance The reported associations of cerebral microbleeds with recurrent stroke and
intracerebral hemorrhage have raised concerns regarding antithrombotic treatment in patients …

Background— Changes in weather and season have been linked to stroke occurrence.
However, the association has been inconsistent across stroke types. Calgary is a city in the …

Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Importance Thrombosis with thrombocytopenia syndrome (TTS) has been reported after
vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford–AstraZeneca) and Ad26.…

Importance Recanalization of intracranial thrombus is associated with improved clinical
outcome in patients with acute ischemic stroke. The association of intravenous alteplase …