The endothelium plays important roles in modulating vascular tone by synthesizing and
releasing a variety of endothelium-derived relaxing factors, including vasodilator prostaglandins, …

Accumulating evidence has demonstrated the importance of reactive oxygen species (ROS)
as an essential second messenger in health and disease. Endothelial dysfunction is the …

Objective— Endothelium-derived nitric oxide (NO) and endothelium-dependent
hyperpolarization (EDH) play important roles in modulating vascular tone in a distinct vessel size–…

Over the past couple of decades, accumulating evidence has shown that structural and
functional abnormalities of coronary microvasculature are highly prevalent, associated with …

There is accumulating evidence highlighting a close relationship between inflammation and
coronary microvascular dysfunction (CMD) in various experimental and clinical settings, …

The endothelium plays a pivotal role in the regulation of vascular tone by synthesizing and
liberating endothelium-derived relaxing factors inclusive of vasodilator prostaglandins (eg, …

In 2008, the Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary
spastic angina) 1 were developed by the Japanese Circulation Society, and the …

Endothelium-dependent relaxations are predominantly regulated by nitric oxide (NO) in
large conduit arteries and by endothelium-dependent hyperpolarization (EDH) in small …

The endothelium plays crucial roles in modulating vascular tone by synthesizing and releasing
endothelium‐derived relaxing factors (EDRFs), including vasodilator prostaglandins, …

Aims: The aim of this study was to test the hypothesis that coronary microvascular endothelial
dysfunction (CMED) is associated with epicardial coronary atherosclerosis. Methods and …