Vitamin C in humans must be ingested for survival. Vitamin C is an electron donor, and this
property accounts for all its known functions. As an electron donor, vitamin C is a potent water…

Background: Vitamin C at high concentrations is toxic to cancer cells in vitro. Early clinical
studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-…

Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …

Early clinical studies showed that high-dose vitamin C, given by intravenous and oral routes,
may improve symptoms and prolong life in patients with terminal cancer. Double-blind …

Background Anecdotal information and case reports suggest that intravenously administered
vitamin C is used by Complementary and Alternate Medicine (CAM) practitioners. The …

The recently released Recommended Dietary Allowance of vitamin C for women, 75 mg
daily, was based on data for men. We now report results of a depletion–repletion study with …

354 JAMC• 6 FÉVR. 2001; 164 (3) dant and, at physiological concentrations, probably does
not produce reactive intermediaries. It protects lowdensity lipoproteins from oxidation, …

A concentration-function approach to vitamin C (ascorbate) has yielded new physiology and
pharmacology discoveries. To determine the range of vitamin C concentrations possible in …

The goals of this work were to establish a reproducible and effective model of apoptosis in a
cell line derived from advanced prostate cancer and to study the role of the caspase family …

Background: When vitamin C intake is from foods, fasting plasma concentrations do not exceed
80 μmol/L. We postulated that such tight control permits a paracrine function of vitamin C. …