SARS-CoV-2 variants of concern (VOC) are more transmissible and may have the potential
for increased disease severity and decreased vaccine effectiveness. We estimated the …

Importance As a result of low numbers of pediatric cases early in the COVID-19 pandemic,
pediatric household transmission of SARS-CoV-2 remains an understudied topic. Objective …

While it is now evident that Omicron is rapidly replacing Delta, due to a combination of
increased transmissibility and immune escape, it is less clear how the severity of Omicron …

Objective: To analyze workplace outbreaks by industry sector in the first wave of the pandemic,
and associated household cases. Methods: Number, size, and duration of outbreaks …

The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated
T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-…

Importance The incidence of SARS-CoV-2 infection, including among individuals who have
received 2 doses of COVID-19 vaccine, increased substantially following the emergence of …

Importance Increased rates of myocarditis or pericarditis following receipt of COVID-19
mRNA vaccines have been observed. However, few available data are associated with …

Purpose: PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy,
yet the frequency of responding patients is limited by inadequate T-cell priming secondary to …

In recent years, monoclonal antibodies (mAbs) able to reinvigorate antitumor T-cell immunity
have heralded a paradigm shift in cancer treatment. The most high profile of these mAbs …

Objective To estimate the effectiveness of mRNA covid-19 vaccines against symptomatic
infection and severe outcomes (hospital admission or death). Design Test negative design …