Background Long working hours might increase the risk of cardiovascular disease, but
prospective evidence is scarce, imprecise, and mostly limited to coronary heart disease. We …

Objective To determine the association between self reported job insecurity and incident
coronary heart disease. Design A meta-analysis combining individual level data from a …

Objective To quantify the association between long working hours and alcohol use. Design
Systematic review and meta-analysis of published studies and unpublished individual …

Background Published work assessing psychosocial stress (job strain) as a risk factor for
coronary heart disease is inconsistent and subject to publication bias and reverse causation …

Background Socioeconomic disadvantage is a risk factor for many diseases. We characterised
cascades of these conditions by using a data-driven approach to examine the association …

Background Although overweight and obesity have been studied in relation to individual
cardiometabolic diseases, their association with risk of cardiometabolic multimorbidity is poorly …

Background The accumulation of disparate diseases in complex multimorbidity makes
prevention difficult if each disease is targeted separately. We aimed to examine obesity as a …

Introduction Higher midlife body mass index (BMI) is suggested to increase the risk of dementia,
but weight loss during the preclinical dementia phase may mask such effects. Methods …

Objective To examine whether physical inactivity is a risk factor for dementia, with attention
to the role of cardiometabolic disease in this association and reverse causation bias that …

Objectives This systematic review and meta-analysis combined published study-level data
and unpublished individual-participant data with the aim of quantifying the relation between …