Background Deep dermatophytosis is a severe and sometimes life-threatening fungal
infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous …

Background A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP)
association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene. …

Background A North American genome-wide single nucleotide polymorphism (SNP) association
study identified IL23R as a novel inflammatory bowel disease (IBD) susceptibility gene. …

Obesity is genetically heterogeneous with monogenic and complex polygenic forms. Using
exome and targeted sequencing in 2,737 severely obese cases and 6,704 controls, we …

Background Clinical, serological, and molecular data support the existence of discrete
subsets of Crohn's disease (CD) defined by location of disease. Little is known about the …

Large-scale gene, protein and metabolite measurements (‘omics’) have driven the resolution
of biology to an unprecedented high definition. Passing from reductionism to a system-…

Background Genetic variation in myosin IXB (MYO9B) was found to be associated with
ulcerative colitis (UC) in a recent collaborative study. A nonsynonymous single nucleotide …

Background Genomewide linkage studies identified chromosome 3p21 as an IBD locus.
Genomewide association studies have supported this locus and the Wellcome Trust Case …

Background: Inflammatory bowel disease is the result of both genes and environment.
Canadian First Nations people, despite living in a region with a high prevalence of inflammatory …

Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory diseases of the
intestine, which can begin at any age, even in children. Both diseases are commonly known …