The advent of gene therapy and polynucleotide‐based vaccines has resulted in the use of
plasmid DNA as a drug substance. Although biologically (cell or animal) based assays must …

Recent studies of human immunodeficiency virus type 1 (HIV-1) infection in humans and of
simian immunodeficiency virus (SIV) in rhesus monkeys have shown that resolution of the …

Adenovirus vectors have attracted considerable interest over the past decade, with ongoing
clinical development programs for applications ranging from replacement therapy for protein …

Stress reactions and stress fractures in the lower extremities occur frequently in military and
athletic populations. As the clinical symptoms of stress fracture may mimic other less severe …

Cellular immune responses, particularly those associated with CD3 + CD8 + cytotoxic T
lymphocytes (CTL), play a primary role in controlling viral infection, including persistent infection …

The recognition of specific pathogen associated molecular patterns (PAMPs) by members of
the Toll-like receptor (TLR) family is critical for the activation of the adaptive immune …

The purpose of this study was to determine whether pre‐ to postoperative increases in
physical activity (PA) are associated with weight loss and health‐related quality of life (HRQoL) …

The ‘typological debate’in archaeology, especially in American archaeology, has been
conducted for several decades now, and the already voluminous literature continues to …

Prescribing exercise based on intensity, frequency, and duration of loading may maximize
osteogenic responses in bone, but a model of the osteogenic potential of exercise has not …

We have evaluated the stability profiles of adenovirus type-5 (Ad5)-based vaccine
formulations to identify liquid formulations that are stable during long-term storage at 4C. By …