Nanoparticle-based medicines in clinical cancer therapy
…, Y Yang, Q Lei, H Huang, Y Yu, Y Fang, Q Tang… - Nano Today, 2022 - Elsevier
Anti-cancer drugs with various mechanisms emerge in succession, but most of free
therapeutics are accompanied by some disadvantages, such as poor safety and effectiveness, …
therapeutics are accompanied by some disadvantages, such as poor safety and effectiveness, …
Drug conjugate-based anticancer therapy-Current status and perspectives
…, Y Jiang, K Cheng, Y Yu, N Jiang, H Miao, Q Tang… - Cancer Letters, 2023 - Elsevier
Drug conjugates are conjugates comprising a tumor-homing carrier tethered to a cytotoxic
agent via a linker that are designed to deliver an ultra-toxic payload directly to the target …
agent via a linker that are designed to deliver an ultra-toxic payload directly to the target …
Efficacy and safety of antiviral treatment for COVID-19 from evidence in studies of SARS-CoV-2 and other acute viral infections: a systematic review and meta-analysis
…, F Liu, X Li, N He, Z Wu, Q Zhang, X Gong, Q Tang… - Cmaj, 2020 - Can Med Assoc
BACKGROUND: Antiviral medications are being given empirically to some patients with
coronavirus disease 2019 (COVID-19). To support the development of a COVID-19 …
coronavirus disease 2019 (COVID-19). To support the development of a COVID-19 …
Landscape and perspectives of macrophage-targeted cancer therapy in clinical trials
S Wang, Y Yang, P Ma, H Huang, Q Tang… - Molecular Therapy …, 2022 - cell.com
Tumor-associated macrophages (TAMs) exert integrated effects in all aspects of tumor
progression, including tumor cell proliferation, angiogenesis, invasion, and metastasis. Recently, …
progression, including tumor cell proliferation, angiogenesis, invasion, and metastasis. Recently, …
Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
…, RO Forsythe, K Tang, Q Tang… - Journal of Cellular …, 2022 - Wiley Online Library
Vascular calcification is associated with aging, type 2 diabetes, and atherosclerosis, and
increases the risk of cardiovascular morbidity and mortality. It is an active, highly regulated …
increases the risk of cardiovascular morbidity and mortality. It is an active, highly regulated …
KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner
Y Peng, S Wu, Q Tang, S Li, C Peng - Journal of Biological Chemistry, 2019 - ASBMB
KGF-1 plays an important role in the wound healing process. Loss of the KGF-1 gene in diabetic
mice attenuated the process of wound contraction, suggesting that KGF-1 contributes to …
mice attenuated the process of wound contraction, suggesting that KGF-1 contributes to …
Topical application of keratinocyte growth factor conjugated gold nanoparticles accelerate wound healing
A Pan, M Zhong, H Wu, Y Peng, H Xia, Q Tang… - … , Biology and Medicine, 2018 - Elsevier
Keratinocyte growth factor (KGF) has been demonstrated to specifically stimulate the
multiplication and migration of keratinocytes. However, due to rapid degradation, the results of …
multiplication and migration of keratinocytes. However, due to rapid degradation, the results of …
TGF‐β‐induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular …
Q Tang, GR Markby, AJ MacNair, K Tang… - Cell …, 2023 - Wiley Online Library
PI3K/AKT/mTOR signalling contributes to several cardiovascular disorders. The aim of this
study was to examine the PI3K/AKT/mTOR pathway in myxomatous mitral valve disease (…
study was to examine the PI3K/AKT/mTOR pathway in myxomatous mitral valve disease (…
Improved stability of KGF by conjugation with gold nanoparticles for diabetic wound therapy
S Li, Q Tang, H Xu, Q Huang, Z Wen, Y Liu… - Nanomedicine, 2019 - Future Medicine
Aim: Diabetic wound healing is seriously interrupted, and administration of KGF for wound
treatment is restricted by its inherent instability. We aim to develop an ideal way toward KGF …
treatment is restricted by its inherent instability. We aim to develop an ideal way toward KGF …
The role of transforming growth factor-β signaling in myxomatous mitral valve degeneration
Q Tang, AJ McNair, K Phadwal, VE Macrae… - Frontiers in …, 2022 - frontiersin.org
Mitral valve prolapse (MVP) due to myxomatous degeneration is one of the most important
chronic degenerative cardiovascular diseases in people and dogs. It is a common cause of …
chronic degenerative cardiovascular diseases in people and dogs. It is a common cause of …
