Context Effective strategies to improve pain management in neonates require a clear
understanding of the epidemiology and management of procedural pain. Objective To report …

Background Multiple organ dysfunction syndrome is more frequent than death in paediatric
intensive care units. Estimation of the severity of this syndrome could be a useful additional …

Objective Anxiety and depression may have a major impact on a person’s ability to make
decisions. Characterization of symptoms that reflect anxiety and depression in family members …

Purpose: Fever induced refractory epileptic encephalopathy in school age children (FIRES)
is a devastating condition initiated by prolonged perisylvian refractory status epilepticus (SE) …

GC is commonly used for the analysis of cannabis samples, eg in forensic chemistry.
However, as this method is based on heating of the sample, acidic forms of cannabinoids are …

All analysts face the same situations as method validation is the process of proving that an
analytical method is acceptable for its intended purpose. In order to resolve this problem, the …

OBJECTIVES: To evaluate the efficacy of cyclosporine A in the treatment of macrophage
activation syndrome (MAS) occurring in children with juvenile arthritis. STUDY DESIGN: MAS …

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated
neurotransmission, have been synthesized: monosubstituted 2-benzothiazolamines and 3-substituted …

From a quality by design perspective, the aim of the present study was to demonstrate the
applicability of a Bayesian statistical methodology to identify the Design Space (DS) of a spray-…

The interaction between sepsis and multiple organ dysfunction syndrome is poorly defined
in children. We analyzed by Cox regression models the cumulative influence of organ …