Background High-dose therapy with supporting autologous stem-cell transplantation remains
a controversial treatment for cancer. In multiple myeloma, first-line regimens incorporating …

Background Methadone, a full mu-opioid agonist, is the recommended treatment for opioid
dependence during pregnancy. However, prenatal exposure to methadone is associated with …

Purpose To examine the effects on process of care and patient well-being, of the regular
collection and use of health-related quality-of-life (HRQL) data in oncology practice. Patients …

High dose melphalan (HDM, 140 mg/m 2 iv) has been evaluated in 58 patients under 63
years with multiple myeloma. Among previously untreated patients 11/41 (27%) entered a …

Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis,
assessment, prevention, and treatment of hypertension in adults and children. This year, …

Introduction In 2008, the UK National Osteoporosis Guideline Group (NOGG) produced a
guideline on the prevention and treatment of osteoporosis, with an update in 2013. This paper …

Proeomics-based approaches, which examine the expressed proteins of a tissue or cell type,
complement the genome initiatives and are increasingly being used to address biomedical …

Hypertension Canada's Canadian Hypertension Education Program Guidelines Task Force
provides annually updated, evidence-based recommendations to guide the diagnosis, …

The Canadian Hypertension Education Program reviews the hypertension literature annually
and provides detailed recommendations regarding hypertension diagnosis, assessment, …

Hypertension Canada’s 2020 guidelines for the prevention, diagnosis, risk assessment, and
treatment of hypertension in adults and children provide comprehensive, evidence-based …