A multi-component meningococcal serogroup B vaccine (4CMenB): the clinical development program

M O'Ryan, J Stoddard, D Toneatto, J Wassil, PM Dull - Drugs, 2014 - Springer
Recently approved in Europe and Australia, the multi-component meningococcal B vaccine,
4CMenB (Bexsero ® , Novartis Vaccines and Diagnostics), contains three surface-exposed …

Considerations for a phase-III trial to evaluate a group B Streptococcus polysaccharide-protein conjugate vaccine in pregnant women for the prevention of early-and …

…, S Schrag, A Izu, A Sobanjo-ter Meulen, PM Dull - Vaccine, 2013 - Elsevier
In 2010, an estimated 393,000 infection-related neonatal deaths occurred worldwide with
Group B streptococcus (GBS) being a leading cause. Prevention of early-onset disease (0–6 …

Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages

M Bröker, PM Dull, R Rappuoli, P Costantino - Vaccine, 2009 - Elsevier
Meningococcal disease is a serious medical condition that can prove fatal within hours in
otherwise healthy individuals. Disease incidence is highest in infants, yet there is no broadly …

Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b/3 randomised …

…, D Toneatto, G Graña, H Wang, R Clemens, PM Dull - The Lancet, 2012 - thelancet.com
Background Effective glycoconjugate vaccines against Neisseria meningitidis serogroups A,
C, W-135, and Y have been developed, but serogroup B remains a major cause of severe …

Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 …

…, D Toneatto, H Wang, M McCarthy, PM Dull… - The Lancet, 2014 - thelancet.com
Background Meningococcal conjugate vaccines protect individuals directly, but can also
confer herd protection by interrupting carriage transmission. We assessed the effects of …

[PDF][PDF] The etiology of febrile illness in adults presenting to Patan hospital in Kathmandu, Nepal

…, CW Woods, MD Zimmerman, PM Dull… - American Journal of …, 2004 - researchgate.net
In Nepal, many infections remain poorly characterized, partly due to limited diagnostic
facilities. We studied consecutive febrile adults presenting to a general hospital in Kathmandu, …

Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial

…, D Pace, LM Yu, JM Langley, S McNeil, PM Dull… - Jama, 2008 - jamanetwork.com
Context Immunization with a meningococcal tetravalent (serogroup ACWY) glycoconjugate
vaccine is recommended for all US adolescents. However, the currently licensed vaccine is …

Safety and immunogenicity of an investigational maternal trivalent group B streptococcus vaccine in healthy women and their infants: a randomised phase 1b/2 trial

…, A Sobanjo-ter Meulen, S Baker, PM Dull… - The Lancet infectious …, 2016 - thelancet.com
Background Maternal group B streptococcus (GBS) serotype-specific capsular antibody
concentrations are correlated with susceptibility to neonatal GBS invasive disease. Maternal …

Immune Responses to Bacillus anthracis Protective Antigen in Patients with Bioterrorism-Related Cutaneous or Inhalation Anthrax

CP Quinn, PM Dull, V Semenova, H Li… - The Journal of …, 2004 - academic.oup.com
Anti-protective antigen (PA) immunoglobulin (Ig) G, toxin neutralization, and PA-specific IgG
memory B cell responses were studied in patients with bioterrorism-related cutaneous or …

Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial

…, M Olugbosi, F Wittke, K Slobod, PM Dull - The Lancet infectious …, 2016 - thelancet.com
Background Neonates born to women infected with HIV are at increased risk for invasive
group B streptococcus (GBS) disease. We aimed to compare safety and immunogenicity of …