NITRIC oxide (NO), a potent vasodilator produced by endothelial cells, is thought to be the
endothelium-dependent relaxing factor (EDRF) which mediates vascular relaxation in …

The COVID-19 pandemic has significantly affected the US health care system. To preserve
resources, including personal protective equipment and hospital beds to care for COVID-19 …

The treatment of ischemic strokes is limited to prophylactic agents that block the coagulation
cascade. Here, we show that cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl (HMG)…

The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains
controversial in part because of the use of nonselective agents that block NO formation in …

By homologous recombination, we have generated mice that lack the neuronal nitric oxide
synthase (NOS) gene. Neuronal NOS expression and NADPH-diaphorase (NDP) staining are …

The metabolic syndrome refers to the co-occurrence of several known cardiovascular risk
factors, including insulin resistance, obesity, atherogenic dyslipidemia and hypertension. …

The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM)
initiation and progression. Here, we examine how EGFR and key downstream signaling …

Nitric oxide (NO) plays a critical role in vascular endothelial growth factor (VEGF)-induced
angiogenesis and vascular hyperpermeability. However, the relative contribution of different …

Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults and remains
incurable despite multimodal intensive treatment regimens. EGFRvIII is a truncated …

Infarct size and vascular hemodynamics were measured 24 h after middle cerebral artery (MCA)
occlusion in mice genetically deficient in the endothelial nitric oxide synthase (eNOS) …