With the emergence of individualized medicine and the increasing amount and complexity
of available medical data, a growing need exists for the development of clinical decision-…

Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

Several mutations in nuclear genes encoding for mitochondrial components have been
associated with an increased cancer risk or are even causative, eg succinate dehydrogenase (…

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

… The authors thank all members of the Boutros lab for support, and especially Dr. Kenneth
Chu and Daryl Waggott for help in generating the windows-compatible version of this package.…

Cancer develops through a process of somatic evolution 1 , 2 . Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

Prostate tumours are highly variable in their response to therapies, but clinically available
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with
checkpoint inhibition, may be an effective treatment approach for glioblastoma. Here in this …

… generate a null MI distribution and P values were calculated as the proportion of null MI
values that were greater than or equal to the true observed MI. P values were FDR-adjusted and …